New synthesis of spirocycles by utilizing in situ forming hypervalent iodine species.

نویسندگان

  • Toshifumi Dohi
  • Tomofumi Nakae
  • Yohei Ishikado
  • Daishi Kato
  • Yasuyuki Kita
چکیده

A very effective spirocyclization procedure for installing nucleophiles (Nu = N(3), NO(2), SCN, SO(2)Tol, and halogens) via iodonium(III) salts has been developed using the combination of iodoarene and mCPBA. The high-yielding syntheses of the cyclohexadienone-type spirocyclic compounds 2 having varied functionalities in the skeletons have been achieved from the aryl alkynes 1 with the optimized bis(iodoarene) 3h.

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عنوان ژورنال:
  • Organic & biomolecular chemistry

دوره 9 20  شماره 

صفحات  -

تاریخ انتشار 2011